Spatial Transcriptomics Reveals Asymmetric Cellular Responses to Injury in the Regenerating Spiny Mouse Ear

August 2023 in “ Genome research ”

Henriëtte van Beijnum, Tim Koopmans, Antonio Tomasso, Vanessa Disela, S. Lindert, Jeroen Bakkers, Anna Alemany, Eugène Berezikov, Kerstin Bartscherer

regeneration hair follicles glands cartilage spatial transcriptomics tomo-seq gene expression immune response

Studysummary This study found that in spiny mice, the proximal side of ear wounds is crucial for regeneration, a process possibly linked to unique injury-induced immune responses compared to nonregenerative rodents.

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research An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice

1 citations , April 2023 in “Science Advances”

This study found that sustained ERK activity during tissue regeneration in spiny mice is linked to fibroblast growth factor and ErbB signaling, while inhibiting ERK shifted regeneration toward scarring.

research Adult Spiny Mice (Acomys) Exhibit Endogenous Cardiac Recovery in Response to Myocardial Infarction

40 citations , November 2021 in “npj Regenerative Medicine”

In this study, spiny mice showed superior cardiac recovery after myocardial infarction compared to other mouse strains, with enhanced myocardial preservation and functional stabilization.

research Scars Or Regeneration? Dermal Fibroblasts As Drivers Of Diverse Skin Wound Responses

123 citations , January 2020 in “International Journal of Molecular Sciences”

This review discusses the role of fibroblast heterogeneity in determining skin scarring versus regeneration and reports no new results, highlighting opportunities for developing antiscarring therapies.

research The Blastema and Epimorphic Regeneration in Mammals

85 citations , December 2017 in “Developmental Biology”

This review discusses mammalian models of epimorphic regeneration to define a vertebrate regeneration blastema, concluding that regenerative failure likely stems from cellular responses to the microenvironment after injury, not progenitor cell availability, and calls for targeted modification studies in mammals to advance human regeneration.

research Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)

418 citations , September 2012 in “Nature”

This study reports the first instance of skin autotomy in mammals, specifically in African spiny mice, and suggests they may possess a greater regenerative capacity than previously understood, possibly offering insights for regenerative medicine.

research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.