Sulforaphane Mobilizes Cellular Defenses That Protect Skin Against Damage by UV Radiation

Topical sulforaphane reduces pigmentation and wrinkles from sun damage.

In this study, broccoli sprout extract and sulforaphane were found to reduce cell viability, suppress growth, and induce apoptosis in breast cancer cells, and oral broccoli sprout extract inhibited tumor growth in animal models, suggesting it may be effective in managing breast cancer.

This article reviews evidence suggesting that vitamin D and its metabolite may help protect against nonmelanoma skin cancer, but reports no new empirical findings.

This study found that Nrf2 activation protected keratinocytes from UVB damage but also caused thickening, inflammation, and cysts, limiting its therapeutic potential for skin protection.

This study found that cis-urocanic acid can engage in non-enzymatic reactions with reactive sulphur species, forming new metabolites, and suggests sulphide donors may protect against UVB-related toxicity.