Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne

    February 2010 in “ Journal of Dermatology ”
    Lingna Li, Li Tang, Eugene Baranov … Robert M. Hoffman
    Studysummary This study observed that a topical liposome formulation of a 5‐α‐reductase inhibitor effectively reduced the size of treated sebaceous glands and induced apoptosis in a hamster model, suggesting potential benefits for acne treatment.
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    Research cited in this study 5

    1. Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear Journal of Investigative Dermatology · 1998
    2. Topical Liposome Delivery of Molecules to Hair Follicles in Mice Journal of Dermatological Science · 1997
    3. Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity Journal of Investigative Dermatology · 1995
    4. Androgens and Human Hair Growth Clinical endocrinology · 1994
    5. Topical Antiandrogens in the Treatment of Male-Pattern Baldness Clinics in dermatology · 1988

    Related research 1

    1. Actions of Isotretinoin and Etretinate on the Pilosebaceous Unit Journal of the American Academy of Dermatology · 1982