Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle

    August 2005 in “ Journal of Investigative Dermatology Symposium Proceedings ”
    Satoshi Itami, Shigeki Inui
    Studysummary This study found that in vitro, beard dermal papilla cells stimulated keratinocyte proliferation via androgen-dependent growth factors, while androgenetic alopecia cells released TGF-β1, inhibiting keratinocyte growth.
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    Research cited in this study 10

    1. Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes Journal of Investigative Dermatology · 2004
    2. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    3. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    4. Conditional Epidermal Expression of TGFβ1 Blocks Neonatal Lethality but Causes a Reversible Hyperplasia and Alopecia Proceedings of the National Academy of Sciences · 2001
    5. Roles of Testosterone in the Growth of Keratinocytes Through Bald Frontal Dermal Papilla Cells Endocrine · 1999
    6. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    7. Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque Endocrinology · 1997
    8. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    9. Interaction Between Dermal Papilla Cells and Follicular Epithelial Cells In Vitro: Effect of Androgen PubMed · 1995
    10. Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp Journal of Endocrinology/Journal of endocrinology · 1992