Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model

    November 2014 in “ Investigative Ophthalmology & Visual Science ”
    Makoto Ishikawa, Takeshi Yoshitomi, Charles F. Zorumski, Yukitoshi Izumi
    Studysummary This study reported that in rat retinas under high pressure, allopregnanolone synthesis increased and helped reduce pressure-induced damage through GABAA receptors, suggesting potential therapeutic use in glaucoma.
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    Research cited in this study 8

    1. Allopregnanolone-Mediated Protective Effects of Progesterone on Tributyltin-Induced Neuronal Injury in Rat Hippocampal Slices The Journal of Steroid Biochemistry and Molecular Biology · 2012
    2. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    3. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    4. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010
    5. Progesterone and Allopregnanolone Enhance the Miniature Synaptic Release of Glycine in the Rat Hypoglossal Nucleus European Journal of Neuroscience · 2009
    6. Role of Neurosteroids in Regulating Cell Death and Proliferation in the Late Gestation Fetal Brain Neuroscience · 2009
    7. Mechanism of Progesterone Neuroprotection of Rat Cerebellar Purkinje Cells Following Oxygen-Glucose Deprivation European Journal of Neuroscience · 2006
    8. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004

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    2. Finasteride Inhibits the Progesterone-Induced Spike-Wave Discharges in a Genetic Model of Absence Epilepsy Pharmacology, Biochemistry and Behavior · 2003