Evolving Approaches to Profiling the Microbiome in Skin Disease

April 2023 in “ Frontiers in immunology ”

Yang Chen, Rob Knight, Richard L. Gallo

microbiome skin disease atopic dermatitis acne psoriasis dysbiosis 16S rRNA gene sequencing metagenomics immune system microbial communities

Studysummary This review discusses the current and emerging methods for profiling skin microbes to advance our understanding of the microbiome in skin disease, but it reports no new clinical findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on frontiersin.org →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research The Human Skin Microbiome in Selected Cutaneous Diseases

47 citations , March 2022 in “Frontiers in cellular and infection microbiology”

This review discusses the role of the skin microbiome in the pathogenesis of various skin disorders, such as atopic dermatitis and psoriasis, and reports no new clinical findings; it emphasizes potential therapeutic implications.

research Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease

41 citations , May 2020 in “Frontiers in immunology”

This review discusses the genetic, autoinflammatory, and keratinization factors involved in hidradenitis suppurativa and presents the concept of classifying it as an autoinflammatory keratinization disease, but reports no new clinical results.

research Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health

65 citations , October 2018 in “Frontiers in cellular and infection microbiology”

This study observed that dandruff in Indian women is associated with a distinct scalp microbiome, including specific bacterial and unknown Malassezia species, with implications for nutrient homeostasis and cell-host adhesion pathways.

research Host-Microbiome Interactions and Recent Progress in Understanding the Biology of Acne Vulgaris

194 citations , October 2018 in “Microbiome”

This study examined recent findings on the role of host-microbiome interactions in acne, highlighting that the skin's microbiome composition differs between acne-affected and healthy individuals and discussing emerging microbiome-based treatments.

research The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls

220 citations , May 2017 in “JAMA dermatology”

This study found that the skin microbiome in patients with hidradenitis suppurativa differs significantly from healthy controls, suggesting a potential link between microbial imbalance and the disease.

research Is There a Gut-Brain-Skin Axis?

185 citations , January 2010 in “Experimental Dermatology”

This study introduces the concept of a "gut–brain–skin axis" where ingesting a specific Lactobacillus strain in mice may reduce stress-induced skin inflammation and hair growth inhibition.