The Keratin 19 Promoter Is Potent for Cell-Specific Targeting of Genes in Transgenic Mice

    June 2001 in “ Gastroenterology ”
    Felix H. Brembeck, Jennifer Moffett, Timothy C. Wang, Anil K. Rustgi
    Studysummary In this study, K19-lacZ transgenic mice exhibited epithelial-specific reporter gene expression in tissues such as the pancreas and stomach, suggesting the K19 promoter is a valuable tool for studying epithelial cell biology.
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    Research cited in this study 5

    1. The Tissue-Dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000
    2. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996
    3. Immunohistochemical Demonstration of Keratin 19 Expression in Isolated Human Hair Follicles Journal of Investigative Dermatology · 1994
    4. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins Journal of Investigative Dermatology · 1989
    5. Differential Expression of Keratin 19 in Normal Human Epithelial Tissues Revealed by Monospecific Monoclonal Antibodies The Histochemical Journal · 1986