Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study

February 2014 in “ Journal of Pediatric and Adolescent Gynecology ”

Mario V. Tartagni, Hala Alrasheed, Gianluca Raffaello Damiani, Monica Montagnani, Maria Antonietta De Salvia, Giovanni De Pergola, Massimo Tartagni, Giuseppe Loverro

finasteride hirsutism polycystic ovary syndrome idiopathic hirsutism Propecia

Studysummary This study found that a low-dose intermittent finasteride regimen significantly reduced hirsutism scores in adolescent girls with PCOS or idiopathic hirsutism, with similar efficacy but potentially safer and less expensive than continuous administration.

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Research cited in this study

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research An Approach to the Patient with Hirsutism

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research The Hirsute Woman: Challenges in Evaluation and Management

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This review discusses the etiology, diagnosis, and management strategies for hirsutism, noting that serious underlying disorders are rare and emphasizing targeted treatment to manage testosterone's effects.

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research Intermittent Low-Dose Finasteride Is as Effective as Daily Administration for the Treatment of Hirsute Women

29 citations , September 2004 in “Fertility and Sterility”

This study found that an intermittent low-dose regimen of finasteride (2.5 mg every 3 days) effectively reduced hirsutism scores in women with idiopathic hirsutism or polycystic ovary syndrome, with fewer side effects than continuous daily administration.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

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research The Evaluation and Management of Hirsutism

195 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”

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research Use of Cyproterone Acetate, Finasteride, and Spironolactone to Treat Idiopathic Hirsutism

56 citations , April 2003 in “Fertility and Sterility”

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research The Benefits of Finasteride for Hirsute Women with Polycystic Ovary Syndrome or Idiopathic Hirsutism

7 citations , February 2003 in “Gynecological Endocrinology”

This study found that finasteride treatment significantly reduced hirsutism and dihydrotestosterone levels in women with idiopathic hirsutism or polycystic ovary syndrome over six months.

research Comparison of High-Dose Finasteride (5 mg/day) Versus Low-Dose Finasteride (2.5 mg/day) in the Treatment of Hirsutism

51 citations , October 2002 in “European journal of endocrinology”

This study found that both high-dose and low-dose finasteride significantly reduced hirsutism scores in women after 12 months, with the lower dose being safe and cost-effective.

research Comparison of Diane 35 and Diane 35 Plus Finasteride in the Treatment of Hirsutism

50 citations , April 2000 in “Fertility and Sterility”

This study found that a combination therapy of Diane 35 with finasteride was more effective at reducing hirsutism scores in women with idiopathic hirsutism or polycystic ovary syndrome after 3 months compared to Diane 35 alone.

research Management of Hirsutism

55 citations , March 2000 in “American journal of clinical dermatology”

Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.

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research A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

113 citations , April 1999 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that all four treatments—flutamide, finasteride, ketoconazole, and EE-CPA—significantly reduced hirsutism, but EE-CPA and flutamide appeared most effective, with varying effects on androgen levels and side-effect profiles.

research Treatment of Hirsutism: Comparisons Between Different Antiandrogens with Central and Peripheral Effects

75 citations , March 1999 in “Fertility and sterility”

This study concluded that finasteride, cyproterone acetate, and flutamide were similarly effective at reducing hirsutism in women, though they acted through different mechanisms.

research Effect of Finasteride in Idiopathic Hirsutism

27 citations , November 1998 in “Journal of Endocrinological Investigation”

This study reported that 6 months of finasteride treatment significantly improved idiopathic hirsutism in women, with benefits persisting 6 months post-treatment and no adverse reactions observed.

Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up

research Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up

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This study found that finasteride effectively reduced hirsutism in women during 12 months of treatment, with some effects persisting in the majority after stopping the medication.

research Clinical Pharmacokinetics and Pharmacodynamics of Finasteride

93 citations , January 1996 in “Clinical Pharmacokinectics”

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research Finasteride

187 citations , January 1994 in “The New England Journal of Medicine”

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers

147 citations , April 1990 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that finasteride significantly suppresses serum dihydrotestosterone levels at all tested doses in normal male volunteers without significant adverse effects.