Mechanisms of Cutaneous Adverse Events During Targeted Cancer Therapy
November 2022
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
EGFR papulopustular rash pruritus dry skin hair morphogenesis skin homeostasis skin barrier defects inflammation type 2 cytokines SOS Ras-Raf-MEK-ERK pathway upper hair follicle epidermal growth factor receptor rash itching hair growth skin balance skin barrier issues cytokines SOS protein Ras-Raf-MEK-ERK signaling pathway hair follicle
Studysummary This study explores how EGFR signaling impacts skin inflammation and follicular integrity during hair eruption, aiming to identify druggable pathways to mitigate skin inflammation in cancer patients receiving EGFR inhibitors.
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