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research Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle

June 2026 in “Science”

This study found that chemically induced skin tumors in mice predominantly originated from Lgr6 + and/or Lrig1 + stem cells of the upper hair follicle rather than from other stem cell populations.

research Early stage alopecia areata is associated with inflammation in the upper dermis and damage to the hair follicle infundibulum

22 citations , June 2013 in “Australasian Journal of Dermatology”

Early stage bald spots are linked to skin inflammation and damage to the upper part of the hair follicle.

research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that hemoglobin α expression in the epidermis is induced by oxidative stress and may function as an antioxidant, contributing to skin barrier function.

research Regeneration of a New Hair Follicle from the Upper Half of a Human Hair Follicle in a Nude Mouse

13 citations , October 2002 in “Journal of Investigative Dermatology”

This study found that only one upper portion of a bisected human hair follicle successfully regenerated a complete new follicle with a pigmented hair in nude mice, although the overall success rate was very low.

research 1030 EGFR protects the upper hair follicle from staphylococcus driven folliculitis

April 2023 in “Journal of Investigative Dermatology”

EGFR helps protect hair follicles from bacterial infections.

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Community Join

5 / 457 results

community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community Baldness Breakthrough: microRNA Stimulates Hair Growth in Aging Follicles

316 upvotes 3 years ago

miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.

community Riken develops new method for culturing hair follicles

41 upvotes 8 years ago

A new stem cell method for culturing hair follicles is being developed as an alternative to Minoxidil, finasteride, and RU58841. There are concerns about its cost and accessibility despite plans for commercialization.

community Table of the relationship between physical exercise and the regeneration of the deminiaturized hair follicle

45 upvotes 1 year ago

Exercise, especially leg workouts, combined with finasteride and minoxidil, may enhance hair regrowth. Cold exposure, like cold showers, might further boost results.

community upped dutasteride from 0,5mg to 3mg and question about my shedding right now

11 upvotes 1 year ago

The user increased their dutasteride dose from 0.5mg to 3mg daily to address hair thinning, noticing a change in shedding patterns and possibly thicker hair. Other users discuss the effectiveness of different dutasteride doses on DHT levels and suggest staying consistent with the treatment.

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Learn

3 / 801 results

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn vitamin A

Are you unknowingly overdoing vitamin A? It could be speeding up hair loss linked to hormones like DHT. Sustained vitamin A intake above the tolerable upper limit (3,000 mcg/day of retinol for adults) is linked in case reports to diffuse hair shedding; the claim that it amplifies DHT-driven hair loss has no published human evidence behind it.

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

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Clinics

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All 13 clinic results →

Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas