Role of 8-Hydroxydeoxyguanosine in Patients With Alopecia Areata

    January 2020 in “ Benha Journal of Applied Sciences ”
    Abd El‐Aziz Ibrahim El‐Taweel, A.I. Mustafa, O.S. El-Shimi, M. A. Abdelzaher
    TLDR 8-OHdG may help diagnose and assess alopecia areata.
    The study investigated the serum level of 8-Hydroxydeoxyguanosine (8-OHdG) in 50 patients with alopecia areata (AA) compared to 30 healthy controls. It found that AA patients had significantly higher levels of 8-OHdG, with a statistically significant difference (P-value = 0.018). The study concluded that 8-OHdG could serve as a promising diagnostic and prognostic biomarker for AA, demonstrating fair diagnostic accuracy with a sensitivity of 70% and specificity of 60% at a cutoff value of 18.1 ng/ml. This suggests that 8-OHdG may be useful in detecting the presence and severity of AA.
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