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    Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice

    March 2015 in “ Nature ”
    René Adam, Hanseul Yang, Shira Rockowitz … Elaine Fuchs
    Studysummary This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.
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    Research cited in this study 5

    1. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    2. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    3. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011
    4. EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair Genes & Development · 2011
    5. The Transcriptional Repressor CDP (Cutl1) Is Essential for Epithelial Cell Differentiation of the Lung and the Hair Follicle Genes & development · 2001