Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart

    October 2007 in “ Journal of Biological Chemistry ”
    Daniel Spira, Jörg Stypmann, Desmond J. Tobin … Thomas Reinheckel
    Studysummary This study concluded that dilated cardiomyopathy in Ctsl-deficient mice is mainly due to the lack of cathepsin L in cardiomyocytes, with additional heart stress from the fur defect.
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    Research cited in this study 3

    1. The Human Cysteine Protease Cathepsin V Can Compensate for Murine Cathepsin L in Mouse Epidermis and Hair Follicles European Journal of Cell Biology · 2004
    2. Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in Nackt Mice, a Cathepsin L-Deficient Mutation American Journal Of Pathology · 2002
    3. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002