A 40-Year-Old Woman of African Descent with Central Scalp Hair Loss

January 2022 in “ Clinical Cases in Dermatology ”

Nkechi Anne Enechukwu

central centrifugal cicatricial alopecia CCCA scarring hair loss trichoscopy topical corticosteroids intralesional corticosteroids antibiotics oral corticosteroids hydroxychloroquine mycophenolate mofetil cyclosporine minoxidil chemical straighteners traction hairstyles topical steroids oral steroids Rogaine

TLDR A woman with CCCA has hair loss due to factors like straighteners and tight hairstyles, and treatments include steroids and avoiding certain hair products.

Central centrifugal cicatricial alopecia (CCCA) is a primary lymphocytic form of scarring hair loss predominantly affecting middle-aged women of African descent. It typically starts at the vertex and spreads centrifugally, often accompanied by itching, pain, and burning sensations. Diagnosis is based on clinical findings and histopathology, with trichoscopy often eliminating the need for a biopsy. Treatment includes potent topical or intralesional corticosteroids, antibiotics, oral corticosteroids, hydroxychloroquine, mycophenolate mofetil, cyclosporine, and minoxidil. Avoiding chemical straighteners and traction hairstyles is recommended.

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research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

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Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.

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community Diffuse hair loss and scalp biopsies

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 89 upvotes 4 months ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 5 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Exploring Bryan Johnson's Hair Routine In Detail

in Research/Science 64 upvotes 11 months ago

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

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