3D Spheroid Culture Synchronizes Heterogeneous MSCs Into an Immunomodulatory Phenotype With Enhanced Anti-Inflammatory Effects

    August 2024 in “ iScience ”
    Ruiqing Lu, Ke Zheng, Yongjie Zhou … Yaojiong Wu
    Studysummary This study found that 3D spheroid culture reprogrammed mesenchymal stem cells into a uniform immunosuppressive phenotype, suggesting potential therapeutic applications for inflammatory diseases like psoriasis.
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    Research cited in this study 1

    1. Single-Cell RNA-Seq Highlights Heterogeneity in Human Primary Wharton's Jelly Mesenchymal Stem/Stromal Cells Cultured In Vitro Stem Cell Research & Therapy · 2020