Vitamin D Activates Type A Natriuretic Peptide Receptor Gene Transcription in Inner Medullary Collecting Duct Cells
April 2007
in “
Kidney international
”
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Studysummary This study found that 1,25 dihydroxyvitamin D3 significantly increased the expression and activity of vasculoprotective natriuretic peptide receptor-A in cultured inner medullary collecting duct cells, suggesting a potential mechanistic role in cardiovascular and renal benefits.
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In the 2007 study, researchers found that 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) significantly increased the expression and activity of the natriuretic peptide receptor-A gene in inner medullary collecting duct (IMCD) cells. This increase was evidenced by doubled production of natriuretic peptide-dependent cyclic guanosine monophosphate, increased receptor protein expression, and higher mRNA levels and gene-promoter activity. The effect was dependent on the presence of a vitamin D response element and the vitamin D receptor, as shown by mutation and interference RNA experiments. These results suggest that vitamin D could positively affect cardiovascular and kidney function by enhancing natriuretic peptide receptor-A expression. However, the study did not provide the number of cells or replicates used in the experiments.
