Metformin Therapy for the Reproductive and Metabolic Consequences of Polycystic Ovary Syndrome

    August 2017 in “ Diabetologia ”
    Susan Sam, David A. Ehrmann
    Studysummary This review discusses genetic factors that may influence the effectiveness of metformin in treating polycystic ovary syndrome and emphasizes the need for further research to establish clear benefits.
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    Research cited in this study 6

    1. American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1 Endocrine Practice · 2015
    2. Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology and Metabolism · 2013
    3. Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome European journal of endocrinology · 2009
    4. Insulin Sensitizers for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials The Journal of Clinical Endocrinology & Metabolism · 2008
    5. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2008
    6. Insulin Administration Alters Gonadal Steroid Metabolism Independent of Changes in Gonadotropin Secretion in Insulin-Resistant Women with Polycystic Ovary Syndrome Journal of Clinical Investigation · 1989