Pleiotropic Role of Notch Signaling in Human Skin Diseases

June 2020 in “ International Journal of Molecular Sciences ”

Rossella Gratton, Paola Maura Tricarico, Chiara Moltrasio, Ana Sofia Lima Estevão de Oliveira, Lucas André Cavalcanti Brandão, Angelo Valerio Marzano, Luisa Zupin, Sérgio Crovella

Notch signaling epidermal cells Hidradenitis Suppurativa Dowling Degos Disease Adams–Oliver Syndrome Psoriasis Atopic Dermatitis

Studysummary This review discusses the role of Notch signaling in skin diseases such as Hidradenitis Suppurativa and Psoriasis, but reports no new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research JMJD3 and NF-κB-Dependent Activation of Notch1 Gene Is Required for Keratinocyte Migration During Skin Wound Healing

54 citations , July 2017 in “Scientific Reports”

This study found that the JMJD3/NF-κB-Notch1 pathway plays a crucial role in regulating keratinocyte migration and skin wound healing, with Notch1 affecting key genes involved in cell migration.

research Mutations in Gamma-Secretase Subunit-Encoding PSENEN Underlie Dowling-Degos Disease Associated with Acne Inversa

87 citations , March 2017 in “Journal of Clinical Investigation”

In this study, researchers identified PSENEN mutations that can lead to a form of Dowling-Degos disease, characterized by follicular hyperkeratosis and an increased susceptibility to acne inversa, especially in the presence of certain trigger factors.

research Anatomy and Function of the Skin

40 citations , January 2016 in “Elsevier eBooks”

This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

61 citations , January 2011 in “PloS one”

In this study, researchers found that Notch signaling is crucial for late-stage epidermal differentiation and postnatal hair cycle homeostasis by regulating hair follicle stem cell proliferation and differentiation.

research More Than One Way to Skin

218 citations , April 2008 in “Genes & Development”

This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.

research Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion

253 citations , April 2008 in “Current opinion in cell biology”

This study found that Notch signalling promotes differentiation of epidermal cells and acts as a tumour suppressor in the skin by interacting with various pathways and mechanisms.