Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice

    December 2004 in “ Neuropharmacology ”
    Doodipala Samba Reddy, Bert W. O’Malley, Michael A. Rogawski
    Studysummary Progesterone reduces anxiety without needing progesterone receptors.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 4

    1. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004
    2. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002
    3. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999
    4. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997

    Related research 2

    1. Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD Psychoneuroendocrinology · 2018
    2. Finasteride Inhibits the Progesterone-Induced Spike-Wave Discharges in a Genetic Model of Absence Epilepsy Pharmacology, Biochemistry and Behavior · 2003