DUPA, Non Responders and Connective Tissue Disorders Research/Science 6/12/2025
A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.
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6 / 1000+ resultscommunity Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated ๐.
Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.
community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism
Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.
community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!
DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.
community Apostles Creed: On The Third Day, He Rose Again From The Dead. 9 Months Dutasteride 1mg daily and Oral Minoxidil 2.5-5mg daily on Diffuse Unpatterned Alopecia
The conversation is about a person's positive experience with Dutasteride 1mg and Oral Minoxidil 2.5-5mg daily for Diffuse Unpatterned Alopecia, showing significant hair regrowth after 9 months. They mention a tough initial shedding phase, no side effects after 9 months, and a preference for oral treatments due to convenience and pet safety.
community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.
A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.
community Questions about DUPA and figuring out what my hairloss is (NEED INPUT BADLY)
The conversation discusses severe hair shedding and thinning, with the original poster using finasteride, oral minoxidil, and other supplements without improvement. The discussion highlights the possibility of telogen effluvium and the importance of addressing potential underlying health issues, such as stress and gut health, rather than assuming diffuse unpatterned alopecia (DUPA).
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