research 090 Stromal re-organization in hair follicle development and cancer suppression
This study suggests that targeting the tumor stroma to promote the formation of dermal condensates may offer a novel approach to treating basal cell carcinoma.
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5 / 1000+ resultsresearch A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease
This study demonstrated that a c-Kit-CreER-driven mouse model confirms melanocyte stem cells as a genuine source of melanoma, paralleling human melanoma in heterogeneity and gene signatures.
research Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.
research 1338 Dermal Wnt/β-catenin activation tunably controls hair follicle initiation
Activating Wnt in skin cells controls the number of hair follicles by directing cell movement and fate.
research Dermal niche signaling and epidermal stem cells
This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.
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