research Sodium Valproate Induced Alopecia: A Case Series
This case series reported three instances where alopecia linked to sodium valproate was reversed after discontinuing the drug.
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5 / 895 results research Dose-dependent valproate-induced alopecia in patients with mental disorders
This study reports that alopecia may develop in patients with chronic exposure to high plasma concentrations of valproate, but resolved after dose reduction or treatment discontinuation.
research Divalproex-Induced Alopecia: A Case Report
This case report describes a woman who experienced complete but temporary scalp hair loss after a massive overdose of divalproex, suggesting a potential acute side effect of the drug.
research Antiseizure Medication-Induced Alopecia: A Literature Review
This review identified alopecia as a significant cosmetic side effect of antiseizure medications, particularly with valproate, lamotrigine, and carbamazepine, noting that hair loss often improves after dose adjustment.
research Baricitinib for Alopecia Universalis Following Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms
Baricitinib effectively regrew hair in a woman with alopecia universalis after other treatments failed.
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3 / 801 results- What is valproic acid, and how did it become a subject of interest in hair growth and alopecia research? Valproic acid is a prescription anticonvulsant that laboratory and mouse studies link to the Wnt/β-catenin hair-growth pathway; one small randomized trial of an 8.3% topical spray reported a hair-count gain over 24 weeks. Oral valproate is also a recognized cause of hair loss and a known teratogen.
- What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? Valproic acid affects hair follicles by modulating cell signaling and gene regulation.
- How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.
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learn Valproic acid
an anticonvulsant repurposed for hair loss via histone inhibition
learn Alopecia Areata
autoimmune disorder causing patchy hair loss
learn Ketoconazole
antifungal with some anti-androgenic benefits, often used as a shampoo
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1 / 1000+ resultscommunity Better Than Minoxidil? Topical Sodium Valproate
Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.
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6 / 41 results- 8Hair SystemsArt of AlopeciaHouston, TX · US
- 21SMPHair Loss TreatmentsMicroScalp Vidalina Alopecia,calvicie, CicatrizBuenos Aires, CABA · AR
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SMPHair Loss TreatmentsThe Alopecia Doctor Hair and Scalp SpaHouston, TX · US - 15Hair SystemsGot Alopecia? Call Keisha!Atlanta, GA · US
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Hair SystemsA BEAUTIFUL YOU ALOPECIA CLINICMauldin, SC · US - 15
Hair SystemsWhat Alopecia? Hair Replacement StudioLynchburg, VA · US
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