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research Ultrahigh-Power Sonicator Lysis Enables Deep Proteomic Profiling of Hair Shafts for Fetal Growth Restriction Biomarker Discovery

November 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

The study introduces an ultrahigh-power sonicator (UHPS) to enhance protein extraction from hair shafts, overcoming the challenge of dense keratinization. This method, combined with Deep Efficient Peptide Sequencing and Quantification (DEEP SEQ) mass spectrometry, allowed for the quantification of 3,925 proteins from just 1 mg of hair. In cases of fetal growth restriction (FGR), 239 differentially expressed proteins were identified compared to healthy controls. These proteins were validated as potential biomarkers using parallel reaction monitoring and ELISA, showing strong correlations with FGR clinical indicators. This UHPS-DEEP SEQ approach represents a significant advancement in noninvasive biomarker discovery for perinatal diagnostics.

research Ultrahigh-Power Sonicator Lysis Enables Deep Proteomic Profiling of Hair Shafts for Fetal Growth Restriction Biomarker Discovery

November 2025 in “Analytical Chemistry”

A new method improves protein extraction from hair, helping identify potential biomarkers for fetal growth issues.

research Monovalent Antibody-Conjugated Lipid-Polymer Nanohybrids for Active Targeting to Desmoglein 3 of Keratinocytes to Attenuate Psoriasiform Inflammation

18 citations , January 2021 in “Theranostics”

The targeted nanohybrids effectively reduced psoriasis symptoms and improved skin health.

research Characterization of Human Ovarian Teratoma Hair Using AFM, FT-IR, and Raman Spectroscopy

3 citations , April 2011 in “Microscopy research and technique”

Teratoma hair is similar to scalp hair but has a rougher surface and lower adhesive force.

research Skin-Inspired Phototherapeutic Cryogel Ameliorates Infected Wound Healing by Orchestrating Mechanotransduction and Immunomodulation

November 2025 in “Bioactive Materials”

The cryogel effectively heals infected wounds and promotes tissue regeneration without scarring.

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4 / 4 results

community Why is Minoxidil not enough for hair loss? (No fin)

in Minoxidil 59 upvotes 1 year ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

community People are hyped about PP405 but what about Veradermics phase 2!

in Research/Science 39 upvotes 2 months ago

Veradermics' phase 2 trial of slow-release oral minoxidil shows promising hair regrowth with minimized side effects, gaining significant attention and funding. PP405 is also noted for its potential as a side-effect-free alternative.

community Reminder: NURTURE those dormant hair follicles for as long as you can until PP405 comes out in 2028-2030

in Treatment 187 upvotes 3 weeks ago

PP405 is anticipated as a future treatment for dormant hair follicles, but its effectiveness and safety are uncertain. Current treatments include oral minoxidil and microneedling, with some avoiding finasteride due to side effects.

community 24M - 14 months of treatment (diffuse thinning)

in Progress Pictures 725 upvotes 3 months ago

A 24-year-old male experienced significant hair regrowth after 14 months of treatment with 0.5mg dutasteride and 5mg minoxidil, with no side effects reported. He plans to consider a hair transplant for his hairline, as the treatment did not improve that area.