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Sinapic Acid and Glabridin Synergistically Mitigate Androgenetic Alopecia by Modulating Ferroptosis Through Stabilization of Beta-Catenin Against Ubiquitin-Dependent Degradation

research Sinapic Acid and Glabridin Synergistically Mitigate Androgenetic Alopecia by Modulating Ferroptosis Through Stabilization of Beta-Catenin Against Ubiquitin-Dependent Degradation

July 2025 in “PubMed”

Sinapic acid and glabridin together help hair growth in androgenetic alopecia.

research Hair Growth-Promoting Activity of Ginsenoside Rf from Panax Ginseng C.A. Meyer, an Industrial Crop-Derived Functional Material

January 2026 in “Industrial Crops and Products”

Ginsenoside Rf from Panax ginseng promotes hair growth and could be a natural alternative for treating hair loss.

Molecular Elements of the Regulatory Control of Keratin Filament Modulator AHF/Trichohyalin in the Hair Follicle

research Molecular Elements of the Regulatory Control of Keratin Filament Modulator AHF/Trichohyalin in the Hair Follicle

7 citations , July 2008 in “Experimental Dermatology”

The study concluded that a protein important for hair strength is regulated by certain molecular processes and is affected by growth phases.

research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations , May 2011 in “APOPTOSIS”

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

Protein Degradation: Expanding the Toolbox to Restrain Cancer Drug Resistance

research Protein Degradation: Expanding the Toolbox to Restrain Cancer Drug Resistance

7 citations , January 2023 in “Journal of Hematology & Oncology”

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

View more "ubiquitin-dependent degradation" in research →

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community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 125 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 132 upvotes 1 year ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.