Search

for
Search:

Research

5 / 1000+ results

research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.

22 citations , October 2001 in “Biochemical Pharmacology”

This study found that GI198745 acts as a time-dependent inhibitor of rat 5α-reductase type 2 but a rapid-equilibrium inhibitor of type 1, potentially making it more effective than finasteride in preventing rat prostate growth.

research The utilisation of cardiac risk ratio and non-HDL cholesterol markers to assess cardiovascular risk in type 2 diabetes males with lowered serum DHT

July 2022 in “International Journal of Health Sciences”

This study assessed lipid parameters and serum DHT levels in type 2 diabetes patients, but the abstract does not specify the findings about their association.

research associations between serum dihydrotestosterone levels, lipid parameters & anthropometric measurements in male patients with type 2 diabetes mellitus

July 2022 in “International Journal of Health Sciences (IJHS) (En línea)”

In this study, researchers found that serum dihydrotestosterone levels were significantly lower in individuals with Type 2 Diabetes compared to healthy controls, with 90% of diabetics displaying subnormal levels.

research Finasteride, a Type 2 5α-reductase inhibitor, in the treatment of men with androgenetic alopecia

32 citations , April 1999 in “Expert Opinion on Investigational Drugs”

Clinical studies reported that finasteride reduces scalp dihydrotestosterone levels and improves hair growth in men with androgenetic alopecia, supporting its role as a treatment option.

research Disorders of sex development (DSD) 46.XY due to type 2 5-α reductase deficiency in three siblings: Case report from a low-resource setting

September 2022 in “Annals of medicine and surgery”

This case report discusses the diagnostic challenges and management options for three siblings with 46, XY DSD due to type 2 5-α reductase deficiency, highlighting the genetic basis and impact on their quality of life.

View more "type 2 dht" in research →

Community Join

5 / 1000+ results

community mangifera indica (mango oil) inhibits dkk1, dht TYPE 2 and activate wnt signal in vivo

6 upvotes 3 years ago

Mango oil may inhibit DKK1 and DHT, potentially aiding hair growth by activating the Wnt signaling pathway. A user plans to test mango leaves juice and other Ayurvedic products for hair regrowth.

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

community We need actual hair loss studies on Epristeride

in Research/Science 6 upvotes 1 year ago

Epristeride is a selective 5 alpha reductase type 2 inhibitor that may reduce scalp DHT similarly to finasteride, with potentially fewer side effects. It is suggested that combining epristeride with finasteride or dutasteride could enhance hair loss treatment effectiveness.

community Dutasteride 0.5 mg/day lowers scalp DHT levels by only 50% (but 2.5 mg/day lowers scalp DHT by 80%).

in Finasteride/Dutasteride 132 upvotes 1 year ago

Dutasteride at 2.5 mg/day reduces scalp DHT by 80%, while 0.5 mg/day reduces it by 50%, with minimal difference in side effects. Users often combine it with finasteride, RU58841, and minoxidil for better hair loss management, though side effects like dry skin and pimples are noted.

community Approximation of Scalp DHT Suppression Between 0.05 mg to 2.5 mg

in Research/Science 63 upvotes 2 years ago

The conversation discusses the effectiveness of various doses of Dutasteride in reducing scalp DHT and its impact on hair count. Users shared personal experiences with hair loss treatments, including Dutasteride, Finasteride, and Minoxidil, with one reporting significant hair loss reduction using a combination of oral Dutasteride and topical Minoxidil and Finasteride.

View more "type 2 dht" in community →

Learn

6 / 800 results

learn white tea

Can white tea help reduce DHT-related hair thinning in androgenic alopecia? In lab tests, tea catechins blocked type 1 (not type 2) 5-alpha-reductase; no human study shows white tea lowers scalp DHT or reduces hair thinning.

learn Dutasteride

A stronger DHT blocker than finasteride, approved for hair loss only in South Korea and Japan and off-label elsewhere, with the same class of side effects and a much longer washout.

learn Finasteride

Prescription tablet (1 mg) that slowed hair loss versus placebo in two-year trials. Labels warn of sexual side effects that have continued after stopping, and of depression and suicidal thoughts; not for use in pregnancy.

learn Neem Oil

Oil from the neem tree, used as a pesticide and in traditional remedies. Human evidence for hair or scalp benefits is limited; it can cause skin allergy and is poisonous if swallowed.

learn Hair Transplant

What are the different hair transplant techniques? The main hair transplant techniques are FUE, DHI, and FUT, each with unique benefits.
Who is a good candidate for a hair transplant? Good candidates for hair transplants have sufficient donor hair and stable hair loss patterns.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

View more "type 2 dht" in learn →

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →