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GlossaryTransglutaminase 3

enzyme crucial for skin and hair protein cross-linking

Transglutaminase 3 (TGM3) is an enzyme that plays a crucial role in the formation and maintenance of the outer layer of the skin and hair follicles. It helps in the cross-linking of proteins, which strengthens the structural integrity of these tissues. Deficiencies or malfunctions in TGM3 can lead to skin disorders and hair loss conditions.

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Lamellar Ichthyosis with Pseudoexon Activation in the Transglutaminase 1 Gene

research Lamellar Ichthyosis with Pseudoexon Activation in the Transglutaminase 1 Gene

10 citations , March 2015 in “Journal of dermatology”

The boy's severe skin disorder is caused by two new mutations in his TGM1 gene.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations , August 2020 in “Cells”

TGM3 is important for skin and hair structure and may help diagnose cancer.

research Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds

8 citations , January 2023 in “International journal of molecular sciences”

Transglutaminase activity is important for skin and is found in both mammals and birds.

research Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?

30 citations , August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

TGase 3 helps build hair structure by forming strong bonds between proteins.

research Transglutaminase 5 Expression in Human Hair Follicle

28 citations , August 2005 in “Journal of Investigative Dermatology”

TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.

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