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GlossaryTransgenic Mice

mice with altered genomes to study specific gene effects

Transgenic mice, also known as genetically modified mice, are mice that have had their genomes altered through the introduction of foreign DNA. This genetic modification allows researchers to study the effects of specific genes on development, physiology, and disease, making them invaluable tools in biomedical research.

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research Long-Term Administration of Triterpenoids From Ganoderma Lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice

9 citations, May 2021 in “Frontiers in aging neuroscience”

Taking triterpenoids from Ganoderma lucidum over a long time can help slow down brain aging and improve overall health in mice.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations, June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

research Transduction-Induced Overexpression of Merkel Cell T Antigens in Human Hair Follicles Induces Formation of Pathological Cell Clusters with Merkel Cell Carcinoma-Like Phenotype

5 citations, August 2021 in “Experimental dermatology”

Overexpressing Merkel cell virus proteins in human hair follicles can create clusters of cells that resemble Merkel cell cancer.

research Development of Heritable Melanoma in Transgenic Mice

75 citations, March 1998 in “Journal of Investigative Dermatology”

The transgene likely activated an oncogene or interrupted a tumor suppressor gene, causing melanoma in mice.

research Skin Wound Healing in Humans and Mice: Challenges in Translational Research

276 citations, December 2017 in “Journal of Dermatological Science”

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 41 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.