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research Interleukin 6: insights to its function in skin by overexpression in transgenic mice.

221 citations , June 1992 in “Proceedings of the National Academy of Sciences”

In this study, IL-6 expression in transgenic mice thickened the stratum corneum without causing increased epidermal proliferation or inflammation, suggesting it may enhance skin protection rather than directly induce inflammation.

research Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene.

93 citations , May 1990 in “The EMBO Journal”

Mice with extra sheep genes had hair that fell out and regrew in cycles.

research Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation

79 citations , August 1998 in “The Journal of Cell Biology”

In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.

research Development of Heritable Melanoma in Transgenic Mice

75 citations , March 1998 in “Journal of Investigative Dermatology”

This study reports that transgenic mice carrying Clone B DNA developed spontaneous melanomas likely due to an interruption in genes regulating cell growth in melanin-producing cells, offering a model for melanoma research.

research Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue

43 citations , February 1999 in “Biochemical Journal”

This study found that transgenic mice overexpressing the SSAT gene under a metallothionein promoter suffered delayed hair loss and were highly sensitive to polyamine analogues, which led to significant liver changes and mortality.

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Community Join

5 / 211 results

community Transient and Permanent Effects of Finasteride Use

158 upvotes 4 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Possible transgenerational effects of finasteride use on male offspring? (STUDY)

in Research/Science 27 upvotes 4 months ago

Finasteride may affect male offspring's fertility and hormonal balance, with debates on whether to discontinue use before conception. Some users report no issues, while others highlight the high doses used in rat studies.

community Regarding a friend who is transgender

2 upvotes 2 years ago

A transgender woman experiencing early hair thinning was advised to consider treatments like dutasteride, finasteride, minoxidil, and cyproterone acetate, especially when starting hormone replacement therapy (HRT). Wigs were discussed as an option, but the drawbacks were highlighted, and consulting a doctor was recommended.

community Stopping Transgender HRT and scared about loosing hair gains

4 years ago

community Your Best Advice on MtF Transgender Hair Transplants

4 upvotes 8 years ago

A 37-year-old transgender woman is considering a hair transplant to improve her hairline, as she has minimal hair loss and is on Spironolactone and Estradiol. Users suggest she is a good candidate for the procedure, advising her to research reputable doctors and clinics.

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Learn

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learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.

learn Follistatin

Is follistatin safe for use in women or transgender individuals undergoing hormone therapy? No study has tested follistatin in women or transgender people on hormone therapy, and it has no approved human use or established dose; the one relevant signal, from a 2023 randomized study in adolescents with PCOS, links higher follistatin to less favourable metabolic markers, so the published evidence does not support using it in this group.

learn Hair Transplant

What should I expect during my consultation for a hair transplant? Expect a scalp assessment, treatment options discussion, and personalized plan during your consultation.
Can a hair transplant be combined with other treatments? Clinics commonly say a transplant is combined with other treatments, most often minoxidil, finasteride or PRP, but the evidence behind each add-on differs. Some of the add-ons offered, such as stem-cell or exosome products, are not approved treatments for hair loss.
How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.

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