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research Substances declared as active ingredients in topical anti-hair loss products – a review of the evidence for their effectiveness in light of clinical studies

June 2026 in “Homo Politicus (Academy of Humanities and Economics in Lodz)”

The effectiveness of ingredients in anti-hair loss products varies, and clinical trials are crucial to determine their success.

research Satisfaction of Patients with Androgenetic Alopecia from a Topical Treatment with TH07 - A New Novel Combination of Substances that Safely Encourage Hair Growth

January 2024 in “JOJ Dermatology & Cosmetics”

This article discusses a trial evaluating patient satisfaction with the TH07 treatment for androgenetic alopecia but reports no clinical results.

research Severe Lichen Planus Pigmentosus Inversus in an Elderly Female Following Intra-Articular Injections of Homeopathic Substances

July 2026 in “Dermato”

In this case study, an 80-year-old woman developed lichen planus pigmentosus inversus after receiving multiple intra-articular injections of a homeopathic preparation, suggesting a possible link, though causality remains speculative.

research Brachioradial pruritus: Treatment with topical capsaicin

56 citations , November 1993 in “Journal of The American Academy of Dermatology”

Capsaicin cream quickly relieved itching in two patients with brachioradial pruritus.

research Topical Application of Aprepitant Inhibits Erlotinib-induced Facial Dermatitis/Hair Loss

January 2024 in “Journal of dermatology and skin science”

In this study, researchers found that applying topical aprepitant, which blocks substance P receptors, significantly reduced facial dermatitis and hair loss in rats experiencing erlotinib-induced skin side effects, highlighting the neurogenic inflammation's role and the protective effect of ROS inhibition.

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Community Join

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community For sublingual minoxidil users and topical minoxidil drinkers : You should STOP spraying topical minoxidil to your mouth NOW. You should consider stopping using a drop of it and mixing it with some other substance too, as you may mess up the dosage

in Minoxidil 183 upvotes 10 months ago

Spraying or drinking topical minoxidil is dangerous and less effective than oral minoxidil. Proper oral minoxidil, like Loniten®, is recommended for safety and effectiveness.

community Should topicals be massaged thoroughly into the scalp ?

4 upvotes 2 years ago

Topicals like minoxidil and finasteride should reach the scalp, but excessive massaging can cause hair to fall out. The evaporation felt is likely the carrier substances like alcohol or propylene glycol.

community Does it work? Maneup GHK-Cu hair growth serum

10 upvotes 2 years ago

The conversation is about the effectiveness of Maneup GHK-Cu hair growth serum, a topical treatment for hair loss. The user is considering trying it but is skeptical due to issues others have had with DIY injections of a similar substance.

community Does anyone think their hair loss is thyroid related?

10 upvotes 1 year ago

Hair loss may be linked to thyroid issues, with some individuals noticing changes in hair texture when taking substances affecting the thyroid. Treatments mentioned include a topical mix of finasteride, minoxidil, and tretinoin, along with microneedling.

community Why isnt topical fin talked about more?

in Chat 44 upvotes 1 year ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

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Learn

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learn GHK-Cu

GHK-Cu: Does it have side effects or is it completely safe? For topical cosmetic use, one 24-hour study in cultured skin cells found a low potential for irritation, but no clinical trial has characterised its side effects on the scalp. Injected or oral GHK-Cu has no published human safety data, and the FDA lists injectable GHK-Cu among compounding substances that may present significant safety risks.

learn Dexpanthenol

Provitamin B5, a moisturiser in hair and skin products

learn Mesotherapy

Injections of drug or vitamin mixtures into the scalp

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin mainly hydrates the hair and scalp; no study has shown that it increases hair thickness or changes follicle function.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

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