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research High‐Potency Topical Steroids: An Effective Therapy for Chronic Scalp Inflammation in Rapp–Hodgkin Ectodermal Dysplasia

3 citations , February 2016 in “Pediatric dermatology”

This report describes two cases of Rapp–Hodgkin ectodermal dysplasia where refractory scalp erosions improved significantly with potent topical steroids; it also suggests a potential link between these scalp conditions and erosive pustular dermatosis of the scalp in elderly patients.

research Topical application of dehydroxymethylepoxyquinomicin improves allergic inflammation via NF-κB inhibition

15 citations , July 2010 in “Journal of Allergy and Clinical Immunology”

This study found that in mouse models, the novel NF-κB inhibitor DHMEQ improved symptoms of atopic dermatitis as effectively as tacrolimus or betamethasone.

research Topical Administration of 15‐Deoxy‐Δ^12,14‐Prostaglandin J₂ Using a Nonionic Cream: Effect on UVB‐Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice

9 citations , January 2021 in “Mediators of Inflammation”

In this study, 15d-PGJ2 administered in a topical cream inhibited oxidative and inflammatory skin changes caused by UVB radiation in hairless mice, suggesting it as a promising treatment approach.

Management of Chemotherapy-Induced Alopecia Using a Topical Botanical Lotion via a Proposed Triple-Action on Apoptosis, Inflammation, and Collagen

research Abstract 3478: Management of chemotherapy induced alopecia using a topical botanical lotion via a proposed triple-action on apoptosis, inflammation and collagen

July 2016 in “Cancer Research”

This study developed a topical botanical lotion for managing chemotherapy-induced hair loss in cancer patients, reporting that it improved hair recovery times by 5-16 weeks, reduced inflammation, and enhanced scalp collagen levels with no observed side effects.

research Topical application of vitamin D cream in particiants with inflammatory acne due to vitamin D deficiency

April 2024 in “International Journal Of Medical Science And Clinical Invention”

This study found that transdermal application of vitamin D cream led to substantial reductions in inflammatory acne among participants with vitamin D deficiency, with all experiencing at least a 30% improvement after one month, and some achieving up to 100% reduction in acne lesions.

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community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 8 months ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community topical cetirizine to control scalp inflammation

4 upvotes 4 years ago

The user applies a topical solution containing minoxidil, finasteride, dutasteride, retinoic acid, and hydrocortisone to address scalp inflammation and is considering adding cetirizine to the mix. They are calculating the correct amount of cetirizine to add to their formula and have paused this approach to retry oral minoxidil.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 5 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community Putting antihistamine cream on scalp to fight inflammation and itchy scalp?

2 upvotes 3 years ago

Topical antihistamine creams, like diphenhydramine, are being considered for scalp inflammation and itchiness as an adjunct to standard hair loss treatments like minoxidil and finasteride. The user is cautious about oral antihistamines due to potential side effects and is exploring topical options.

community I always hear the advice to reduce scalp inflammation. What are some non-steroidal ways to reduce inflammation?

in Treatment 13 upvotes 1 year ago

Non-steroidal ways to reduce scalp inflammation include using topical melatonin, urea shampoo, Zyrtec, turmeric with black pepper, omega-3 supplements, a self-made topical solution with cetirizine, melatonin, and piroctone olamine, ketoconazole shampoo, witch hazel shampoo, tacrolimus, and lifestyle changes like a healthy diet and regular exercise. Some users also mentioned unconventional methods like infrared light therapy and a carnivore diet.

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Learn

8 / 801 results

learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.
What makes cetirizine a unique anti-inflammatory option for your scalp? Laboratory work reports that cetirizine lowers PGD2 and other inflammatory mediators, which is why researchers have proposed it for the scalp. There is no approved topical product and the clinical evidence is one small unblinded pilot study in pattern hair loss, so scalp use is off-label and experimental.

learn Hydrocortisone

a synthetic cortisol used for anti-inflammatory effects

Is hydrocortisone effective for stopping inflammation that blocks hair growth? Sources describe hydrocortisone as a short-course treatment for scalp inflammation such as seborrhoeic dermatitis or eczema, and no verified trial tests it as a hair-regrowth treatment; the corticosteroids used for alopecia areata are the potent prescription ones, and prolonged use of any topical steroid on the scalp risks skin thinning.

learn Fluocinolone

What type of hair loss is Fluocinolone recommended for, and how does it help inflamed scalps? Fluocinolone is a prescription topical corticosteroid used for inflammatory scalp conditions such as seborrheic dermatitis, scalp psoriasis and scarring alopecias. It calms inflammation rather than growing hair, it is not a treatment for pattern hair loss, and its labelling warns against prolonged use.

learn Metformin

diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Centella

Not eating well lately and your hair’s falling? A centella-based supplement might give your roots the boost they’re begging for. There is no published human trial showing that an oral Centella asiatica (gotu kola) supplement stops hair shedding caused by poor nutrition; the evidence is laboratory work on dermal papilla cells, inflammation and collagen, and community reports mention centella only in topical products.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Lavender

plant and natural oil with antimicrobial and some anti-androgenic effects

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