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Research

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Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

research 139 Anti-BCC efficacy of a topical hedgehog inhibitor without adverse effects in BCNS patients in a phase 2 randomized controlled trial

1 citations , April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that topical patidegib gel significantly shrank basal cell carcinomas in Gorlin syndrome patients without causing the systemic side effects common with oral hedgehog inhibitors.

research Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients

48 citations , November 2017 in “Journal of the American Academy of Dermatology”

Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.

Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

In this study, TASP0382088 showed potent selective inhibition of the ALK5 receptor, significantly reducing Smad2 phosphorylation in mouse skin following topical application.

research Randomized controlled trial to compare the efficacy of oral minoxidil 1.25 mg versus 2.5 mg versus topical 5% minoxidil in androgenetic alopecia

January 2026 in “Dermatologica Sinica”

In this study, oral minoxidil (1.25 mg and 2.5 mg) and topical 5% minoxidil significantly promoted hair regrowth in men with androgenetic alopecia over six months, showing comparable efficacy across both oral and topical treatments.

research Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual‐acting” (2 for 1) plant‐based peptides, hormones, and cannabinoids

13 citations , May 2021 in “FASEB bioAdvances”

This review discusses plant-based alternatives to retinoids for dermal antiaging and hair health, highlighting roles for cytokinins and phytoestrogens and reports no new results.

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Community Join

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community 2.5 years on topical finasteride (0.1% fin + 7% min): hair success and why I stopped

in Finasteride/Dutasteride 20 upvotes 7 months ago

Topical finasteride with minoxidil effectively stabilized and thickened hair but caused side effects like brain fog, reduced libido, and emotional flattening, leading to discontinuation. The user switched to a new regimen including minoxidil, KX-826, and other treatments, noting improvements in libido and vivid dreams after stopping finasteride.

community Topical fin (0.1%) and min (5%) for almost 2 years

in Progress Pictures 11 upvotes 3 months ago

A 25-year-old male has been using topical finasteride (0.1%) and minoxidil (5%) for almost two years with no visible improvement but stable hair loss. Suggestions include switching to oral finasteride and minoxidil, considering stronger treatments like dutasteride, and consulting a doctor for personalized advice.

community topical min 2 years, topical fin 1 year

in Progress Pictures 8 upvotes 4 months ago

The user shared progress pictures showing improved hair density after using topical Minoxidil for two years and topical Finasteride for one year, with occasional microneedling. They adjusted Finasteride concentration over time and are considering additional treatments like a hair transplant.

community Used topical fin for 2 years, can i add oral fin too? (18 Male)

in Finasteride/Dutasteride 4 upvotes 4 months ago

An 18-year-old male using topical finasteride and minoxidil for hair loss is considering adding oral finasteride. Users advise against combining both forms of finasteride due to increased side effects and suggest switching to oral finasteride or dutasteride for better results, noting that finasteride is less effective on hairlines.

community Can you see any progress in 2.5 months (on topical + 1 mg Finasteride)

in Progress Pictures 4 upvotes 1 month ago

The user is using topical Minoxidil 5% and 1 mg Finasteride for hair loss and believes there is progress in 2.5 months, though opinions on progress vary. Some users see modest improvement, while others suggest better photo consistency for clearer assessment.

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Learn

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learn Minoxidil

Minoxidil 2%, 5% and 10% which is better to use? In a randomized trial in men, 5% topical minoxidil produced more hair growth than 2%. There is no approved 10% product and no head-to-head trial showing it beats 5%; higher strengths mainly add irritation and systemic absorption. Approved strengths differ by sex, so check the label for your product.

learn TDM-105795

How is TDM-105795 used in hair-related products, and is it being explored as a topical treatment, an oral option, or both? TDM-105795 is not sold in any hair product — it is an unapproved experimental compound. The public trial registry shows it has been studied only as a topical scalp solution, in three completed company trials (the largest a 71-participant, 16-week Phase 2); no oral programme is registered, and no peer-reviewed publication exists.

learn Hair Transplant

How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.
How much does a hair transplant cost? Hair transplant costs typically range from $1,000 to $25,000 depending on various factors.

learn Procyanidin

How long should Procyanidin be used before seeing visible improvements in hair volume or density? The two published human trials of 1% topical procyanidin B-2 measured results at four and six months, so any visible change would take at least that long. Both were small, industry-run studies in men only, and procyanidin is not an approved hair-loss treatment.