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research 3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration

15 citations , March 2022 in “Acta Biomaterialia”

This study demonstrated that a 3D bioprinting technique using a gelatin/alginate hydrogel scaffold can regenerate entire hair follicles in mice, offering potential advancements in hair loss treatment.

research Corrigendum to ‘3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration’ [Acta Biomaterialia (2022)]

December 2022 in “Acta Biomaterialia”

Corrections were made to a previous work on 3D printing a gel-alginate mix for creating hair follicles, but the main finding - that this method can help grow hair - remains the same.

research Tissue-Engineered Skin Preserving the Potential of Epithelial Cells to Differentiate into Hair After Grafting

24 citations , October 2010 in “Tissue Engineering Part A”

This study found that tissue-engineered skin using mouse fibroblasts successfully supported hair growth after grafting, but similar success was not observed using human fibroblast-derived tissue.

research 918 Tissue engineered human hair follicles from genetically, environmentally and extrinsically reprogrammed dermal papilla cells

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reports that incorporating Lef-1 transfected dermal papilla cells into human skin equivalents significantly promoted hair follicle differentiation and hair fiber growth, offering a potential advancement for managing skin loss.

research In vitro interactions between sensory nerves, epidermis, hair follicles and capillaries in a tissue‐engineered reconstructed skin

September 2004 in “Experimental Dermatology”

This study developed a tissue-engineered model of innervated skin, allowing for examination of how epidermis and capillaries affect nerve growth and offering a tool for further research on skin-related processes.

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community Genuine question about VDPHL01's long term safety that I haven't seen discussed here

in Research/Science 28 upvotes 4 months ago

Concerns about the long-term safety of VDPHL01, an extended-release minoxidil, due to potential risks similar to Cantu syndrome, were raised, highlighting the lack of monitoring for chronic connective tissue changes. The conversation suggests that while the treatment may improve hair growth, it could lead to issues not detected in short-term trials.

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

106 upvotes 10 months ago

PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 1 year ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community Deoxyribose sugar gel worked just as well as minoxidil

in Research/Science 18 upvotes 1 year ago

A deoxyribose sugar gel may work as well as minoxidil for hair regrowth by boosting blood supply to hair follicles. Some users discuss combining it with minoxidil and cetrizine, but caution is advised due to potential risks and lack of consistent results.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Beta Polypeptide

learn Platelet-Rich Plasma

growth factors taken from your blood and injected into your scalp to stimulate hair

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn Verteporfin

chemical that might completely regrow follicles from hair transplant extractions

learn TDM-105795

What is TDM-105795, and why is it being studied as a potential product for hair loss and hair growth support? TDM-105795 is an experimental drug aimed at treating androgenetic alopecia to promote hair growth.

learn Hair Transplant

Can beard hair be used for hair transplants? Beard hair can be effectively used for hair transplants, especially when scalp hair is limited.

learn SCUBE3

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

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