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research The Anthropogenic Disappearance of Inorganic Tin (Stannum) as a Hidden Driver of Myocardial Insufficiency and Symmetrical Androgenetic Alopecia: A Novel Pathophysiological Hypothesis

September 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

In this paper, the authors propose that a historical decline in dietary tin intake may contribute to cardiovascular issues and accelerate pattern hair loss by causing copper and zinc depletion, which impairs heart function and scalp circulation.

research The Anthropogenic Disappearance of Inorganic Tin (Stannum) as a Hidden Driver of Myocardial Insufficiency and Symmetrical Androgenetic Alopecia: A Novel Pathophysiological Hypothesis

September 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

In this paper, the authors propose that a major reduction in dietary tin over the past century could be linked to increased cardiovascular issues and androgenetic alopecia, hypothesizing that tin deficiency disrupts heart function and scalp circulation by depleting copper and zinc.

research Longitudinal clinical course in patients with 5α-reductase type 2 deficiency treated with testosterone and dihydrotestosterone during infancy and puberty

October 2022 in “Endocrine journal”

In this study of male patients with 46,XY 5α-reductase type 2 deficiency, DHT therapy was effective in achieving penile enlargement during infancy, while testosterone replacement therapy proved more beneficial during puberty, possibly due to increased conversion to DHT.

research Testosterone therapy in men: Clinical and pharmacological perspectives

25 citations , March 2000 in “Journal of Endocrinological Investigation”

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

research Serum C-19 steroid sulphates in females with clinical hyperandrogenism

4 citations , January 1989 in “Journal of Steroid Biochemistry”

This study suggests that 5-ADIOL-S may contribute to the synthesis of potent androgens in peripheral tissues, and 3 alpha-DIOL-S could be a marker of androgen metabolism in various female patient groups.

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community I don’t understand this, is he equating taking Fin with being on HRT?

303 upvotes 1 year ago

The conversation is about using finasteride and testosterone replacement therapy (TRT) for hair loss and their role in gender-affirming care. It debates whether these treatments are considered hormone replacement therapy (HRT) and their implications for both cisgender and transgender individuals.

community Blaming Finasteride doesn't help you solve anything: dry eyes

51 upvotes 1 year ago

Finasteride is debated for causing dry eyes, with some users experiencing relief after stopping it, while others find no connection. Topical treatments like dutasteride and minoxidil are suggested as alternatives, with advice to consult medical professionals.

community What to do if fin is still not working after 2.5 years

in Finasteride/Dutasteride 22 upvotes 1 year ago

The user is experiencing increased hair loss despite using finasteride and oral minoxidil and is hesitant to switch to dutasteride due to side effects and family planning concerns. Alternatives suggested include dutasteride, microneedling, and addressing stress or nutrient deficiencies.

community Regular middle aged guy, taking 5mg minoxidil, 1.1mg finasteride and biotin combo pill. 3 months progress.

151 upvotes 1 year ago

A 45-year-old man experienced positive hair regrowth using a combination pill of 5mg minoxidil, 1.1mg finasteride, and 1mg biotin over three months. He reported minimal side effects and prefers this treatment over hair transplants.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 7 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

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research The Anthropogenic Disappearance of Inorganic Tin (Stannum) as a Hidden Driver of Myocardial Insufficiency and Symmetrical Androgenetic Alopecia: A Novel Pathophysiological Hypothesis

research The Anthropogenic Disappearance of Inorganic Tin (Stannum) as a Hidden Driver of Myocardial Insufficiency and Symmetrical Androgenetic Alopecia: A Novel Pathophysiological Hypothesis

research Longitudinal clinical course in patients with 5α-reductase type 2 deficiency treated with testosterone and dihydrotestosterone during infancy and puberty

research Testosterone therapy in men: Clinical and pharmacological perspectives

research Serum C-19 steroid sulphates in females with clinical hyperandrogenism

Community Join

community I don’t understand this, is he equating taking Fin with being on HRT?

community Blaming Finasteride doesn't help you solve anything: dry eyes

community What to do if fin is still not working after 2.5 years

community Regular middle aged guy, taking 5mg minoxidil, 1.1mg finasteride and biotin combo pill. 3 months progress.

community How is dht not beneficial to you?

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