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DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

research DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

56 citations , February 2010 in “PLOS ONE”

Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.

Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

32 citations , May 2012 in “PloS one”

Thymic transplantation normalized some T-cells but not others, maintaining immune function.

research Decision Letter: IL-18 Signaling Promotes Homing of Mature Tregs into the Thymus

May 2020

IL-18 signaling helps mature Tregs move into the thymus.

research IL-18 Signaling Promotes Homing of Mature Tregs into the Thymus

July 2020

IL-18 signaling helps mature Tregs move into the thymus.

Mucosal TLR5 Activation Controls Healthspan and Longevity

research Mucosal TLR5 Activation Controls Healthspan and Longevity

1 citations , January 2024 in “Nature communications”

Activating TLR5 in the gut can extend lifespan and improve health in aged mice.

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