Angelica Sinensis Promotes Cortical Regeneration Of The Thymus In Mice With Acute Thymic Involution Induced By Short-Term Rapamycin Treatment

The study involving 72 female BALB/c mice found that Angelica sinensis significantly promotes thymus cortical regeneration and increases cortical thymic epithelial cell density in mice with acute thymic involution induced by short-term rapamycin treatment. High doses of Angelica sinensis improved thymus structure, increased cortical area, and enhanced expression of key genes crucial for TEC function, such as Foxn1 and Dll4. Additionally, the herb activated the Wnt/CTNNB1 signaling pathway, reduced inflammation, and promoted hematopoietic stem cell homing, facilitating thymic recovery. These findings suggest Angelica sinensis could mitigate rapamycin's adverse effects on the thymus, supporting its potential use in anti-aging and immune health interventions.