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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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5 / 19 resultslearn Thymosin Beta 4
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An essential vasodilator with some anti-androgenic effects, has excellent safety record
Research
5 / 1000+ resultsresearch Predicting Therapeutic Drugs for Hepatocellular Carcinoma Based on Tissue-Specific Pathways
Securinine and ajmaline may effectively treat liver cancer, with securinine being less toxic to normal cells.
research Platinum-Induced Peripheral Neuropathy: ROS-Related Mechanism, Therapeutic Agents, and Nanosystems
Reducing reactive oxygen species can help treat nerve damage from platinum cancer drugs.
research Drug Repurposing: Hypothesis, Molecular Aspects, and Therapeutic Applications
Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.
research Ethnobotanical Uses, Phytochemistry, and Pharmacological Activities of Peperomia Pellucida (L.) Kunth (Piperaceae) - A Review
Peperomia pellucida shows promise for developing new therapeutic drugs.
research Hair
Hair can reveal toxic elements and drugs in the body.
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5 / 199 resultscommunity How to BECOME a RESPONDER to Fin/Dut if you are not responding
The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.
community I think I’m actually winning (take ur drugs lads)
A 24-year-old male experienced hair loss and successfully treated it using a combination of Finasteride, Dutasteride, and Oral Minoxidil. He reported no side effects and plans to continue the treatment to maintain his hair.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found
The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.
community Effectiveness of Dutasteride 0.5mg: Scalp vs Follicle DHT Reduction for AGA
Dutasteride 0.5 mg significantly reduces both scalp and hair follicle DHT, with a greater reduction in hair follicle DHT. The discussion questions which reduction is more important for androgenetic alopecia and diffuse thinning.