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    GlossaryTen-Eleven Translocation Methylcytosine Dioxygenase (Tet1)

    enzyme that modifies DNA to regulate gene expression

    Ten-Eleven Translocation Methylcytosine Dioxygenase, often abbreviated as TET, is an enzyme that plays a crucial role in DNA demethylation, a process that can activate or deactivate genes. TET enzymes modify methylated cytosines (a component of DNA) by converting them into hydroxymethylcytosines, which can then be further processed to remove the methyl group entirely. This activity is essential for regulating gene expression and maintaining normal cellular functions, and disruptions in TET function have been linked to various diseases, including cancer.

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