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Inhibitory Activities of Some Traditional Chinese Herbs Against Testosterone 5α-Reductase and Effects of Cacumen Platycladi on Hair Regrowth in Testosterone-Treated Mice

research Inhibitory activities of some traditional Chinese herbs against testosterone 5α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice

25 citations , November 2015 in “Journal of Ethnopharmacology”

This study found that Cacumen platycladi extract significantly promoted hair growth and reduced dihydrotestosterone levels by inhibiting 5α-reductase activity in an androgen-sensitive mouse model.

Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

124 citations , March 2012 in “JAMA”

This abstract discusses the unclear role of dihydrotestosterone (DHT) in postembryonic life in marsupials and possibly humans, reporting no new findings.

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.

research Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors – dutasteride and finasteride – in the presence of testosterone

1 citations , June 2021 in “Singapore Medical Journal”

This study suggests that type I 5-alpha reductase may also play a role in hair growth, with dutasteride potentially being more potent than finasteride in modulating key hair growth gene expressions.

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Community Join

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community Does caffeine inhibit 5-α-reductase?

4 upvotes 6 years ago

Caffeine may promote hair growth and potentially inhibit 5-α-reductase activity in hair follicles, but its effectiveness and systemic impact remain unclear. Users discuss using topical caffeine solutions, with some experiencing no side effects compared to finasteride.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

community 17-alpha-estradiol/Alfatradiol how does it Work for Hair loss?

2 upvotes 1 year ago

17-alpha-estradiol may work for hair loss by inhibiting 5-alpha reductase, similar to finasteride. It might lower testosterone in the scalp, reducing DHT conversion.

community Creatine and Weird Conclusion in a Study?

4 upvotes 2 years ago

Creatine may temporarily increase testosterone but likely has minimal impact on hair loss, especially when using 5-alpha reductase inhibitors like finasteride. Some users stopped creatine due to hair loss concerns, but results are unclear due to concurrent use of treatments like topical finasteride and microneedling.

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Learn

6 / 12 results

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

learn Rosemary

herb and oil with stimulant, circulatory, anti-inflammatory and antioxidant properties

learn Bicalutamide

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

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