This narrative review highlights the critical role of intracrine hormone production in peripheral tissues, suggesting that continuous-release subcutaneous testosterone pellet therapy may offer a more effective symptom-driven approach for aging populations, though large-scale randomized controlled trials are needed for confirmation.
2 citations
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January 2018 in “International Journal of Trichology” This report presents a case of new-onset androgenic alopecia in a patient following the use of the hCG diet combined with testosterone pellet implantation.
2 citations
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March 2004 in “Reviews in Gynaecological Practice” This review discusses treatments for female sexual dysfunction in postmenopausal women, noting that the effectiveness of current pharmaceutical options is inconclusive and emphasizing the importance of individualized care.
This study reports that subcutaneous testosterone pellets in peri- and postmenopausal women provided sustained hormone release and potential benefits for sexual function, but raised concerns about safety, variability, and dosing inconsistencies.
May 2021 in “Journal of the Endocrine Society” This case report highlights the adverse effects of unmonitored bioidentical hormone replacement therapy, emphasizing the need for patient education about its safety and efficacy compared to FDA-regulated hormones.