March 2026 in “Seven Editora eBooks” This systematic review evaluates the composition, mechanisms, efficacy, safety, and risks of topical testosterone formulations, such as creams, gels, ointments, and transdermal patches, used primarily by middle-aged and elderly men. The review, covering studies from 2010 to 2025, finds that while testosterone creams have variable absorption, gels provide stable bioavailability, and patches ensure continuous release. Despite their effectiveness in increasing serum testosterone levels, these formulations can lead to adverse effects like acne, gynecomastia, alopecia, and potential stimulation of prostate or breast cells. The study concludes that due to significant systemic risks, these products should only be used under strict medical supervision.
6 citations
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January 2020 in “The Aging Male” Testosterone replacement therapy improved blood sugar and fat levels without raising prostate cancer risk in Japanese men with low testosterone.
19 citations
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May 2020 in “American journal of men's health” Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.
4 citations
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December 2014 in “PubMed” Pre-operative hormone treatment for hypospadias surgery might improve outcomes, but more research is needed to confirm.
1 citations
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February 1954 in “Journal of the American Geriatrics Society” Steroid hormones can help treat aging issues and improve health in elderly people.