The Five-Year Effects of Testosterone Replacement Therapy on Lipid Profile and Glucose Tolerance Among Hypogonadal Men in Japan: A Case Control Study

    January 2020 in “ The Aging Male ”
    Yuki Kato, Kazuyoshi Shigehara, Kazufumi Nakashima, Masashi Iijima, Shohei Kawagushi, Takahiro Nohara, Kouji Izumi, Yoshifumi Kadono, Hiroyuki Konaka, Mikio Namiki, Atsushi Mizokami
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    TLDR Testosterone replacement therapy improved blood sugar and fat levels without raising prostate cancer risk in Japanese men with low testosterone.
    The study from 2020 investigated the long-term impact of testosterone replacement therapy (TRT) on the metabolic health of 14 Japanese hypogonadal men over a period of 5 years, using monthly intramuscular injections of testosterone enanthate (250 mg). Compared to 22 control subjects, the TRT group showed significant improvements in fasting blood sugar (FBS), hemoglobin A1c (HbA1c), and triglyceride (TG) levels at various intervals, without a significant increase in prostate-specific antigen (PSA) levels. Despite the small sample size and potential biases, the findings suggest that TRT may have beneficial effects on lipid profile and glucose tolerance in this population, with no increased risk of prostate cancer. Further research with a larger cohort is necessary to validate these results.
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