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5 / 1000+ resultsresearch Increase in CD8+ Effector Memory Cells Re-Expressing CD45RA Reflects Disease Activity and Enables Early Prediction of Therapeutic Outcome in Rapidly Progressive Alopecia Areata
This study investigated the role of CD8+ effector memory cells re-expressing CD45RA (TEMRA) in rapidly progressive alopecia areata (RPAA) and their potential to predict therapeutic outcomes following intravenous corticosteroid pulse therapy (IVPT). Involving 26 RPAA patients, the study found that TEMRA cells were significantly increased in non-responders (those with < 50% hair regrowth) compared to responders, both before and after IVPT. Non-responders' TEMRA cells exhibited 3.3-fold greater cytotoxicity when exposed to trichohyalin. Histological analysis showed a higher proportion of TEMRA cells in non-responders' peribulbar regions, correlating with their frequency in peripheral blood mononuclear cells (r = 0.74). These results suggest that monitoring TEMRA cells could help evaluate disease activity and predict therapeutic outcomes in RPAA.
research Wound Healing and the Use of Medicinal Plants
Some medicinal plants can help heal wounds and may lead to new treatments.
research What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses
Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.
research Novel TMEM173 Mutation and the Role of Disease-Modifying Alleles
A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.
research Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice
Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.
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5 / 49 resultscommunity Has anyone tried KeraXL before?
A user discussed using KeraXL serum for hair loss, which contains Biochanin-A from Red clover extract and Acetyl Tetrapeptide-3. They sought feedback on its safety and effectiveness.
community What is your opinion on HMI-115?
HMI-115, a potential treatment for hair loss that has been reported to produce significant regrowth in bald areas. It is the closest thing to a cure currently available and has raised hope that it could make hair transplants obsolete.
community Stem Cells May Get Rid Of Balding FOREVER!
Stem cell therapy shows promise in treating hair loss by mimicking DHT-resistant cells from the back of the head. Traditional treatments like finasteride are also discussed, but stem cells could potentially offer a more permanent solution.
community best way make topical melatonin solution
A user wants to try melatonin for hair loss by mixing melatonin powder with a topical oil serum. They are asking if this mixture is possible and effective.
community The worst part of balding is its harder to maintain a balding head
The conversation discusses the challenges of maintaining a balding head, with some preferring to shave regularly and others choosing to embrace their hair loss. Specific treatments or concerns about hair transplants and societal perceptions of balding are also mentioned.