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research Telomere Dynamics and Telomerase in the Biology of Hair Follicles and Their Stem Cells as a Model for Aging Research

12 citations , January 2021 in “Journal of Investigative Dermatology”

Hair follicle studies suggest that maintaining telomere length could help treat hair loss and graying, but it's uncertain if mouse results apply to humans.

research Molecular Regulation of Melanocyte Senescence

85 citations , July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

research Anabolic Androgenic Steroids and Carcinogenicity Focusing on Leydig Cell: A Literature Review

65 citations , April 2018 in “Oncotarget”

Anabolic androgenic steroids can increase cancer risk and disrupt hormones.

research Human Skin Stem Cells and the Aging Process

143 citations , September 2008 in “Experimental gerontology”

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

research Aging of the Hair Follicle Pigmentation System

75 citations , January 2009 in “International journal of trichology”

Hair grays due to oxidative stress and fewer functioning melanocytes.

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Community Join

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community Hair loss research is a money grab

in Chat 217 upvotes 1 month ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 44 upvotes 11 months ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community 2.5 yrs progress: Min + dermaroll + niz

in Progress Pictures 76 upvotes 3 years ago

A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.

community Is this real chat? Finasteride -> fountain of youth and longevity drug?

in Finasteride/Dutasteride 558 upvotes 3 months ago

Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.

community PP405 Might Be the Closest We Have to a Upcoming Cure

in Technology 237 upvotes 11 months ago

PP405 is considered a promising potential cure for hair loss, with phase 2 trial results expected in February 2025. Hair cloning is also discussed as a potential ultimate solution, despite significant scientific challenges.

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