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In this study, researchers isolated multipotent stem cells from elderly human epidermis and showed that they could differentiate into neurons using TAT-VHL peptide, suggesting potential for regenerative therapies.

This review highlights the potential of peptide-based PROTACs (pPROTACs) in expanding the target range of protein degraders beyond small-molecule limitations, particularly for undruggable proteins, by utilizing advances in design, conjugation, and bioPROTAC technology.

This review detailed the significant progress and challenges in the design and application of PROTACs, a novel class of cancer therapeutics, highlighting their clinical trials, design complexities, and the role of artificial intelligence in improving their efficacy and selectivity for cancer therapy.

This study found that nestin-negative hair follicle stem cells can differentiate into neural stem cell-like cells, but not mature neurons, through a multi-step neuro-induction process.

This review discusses the development and clinical progression of PROTAC technology for targeted protein degradation, highlighting its potential to address previously "undruggable" targets but reports no new clinical results.