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research Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing

34 citations , June 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.

research Regulation of immune response genes in the skin of allergic and clinically tolerant individuals exposed to p‐phenylenediamine

4 citations , January 2024 in “Allergy”

This study indicates that individuals exposed to PPD mount varying immune responses, with either tolerance, subclinical inflammation, or allergy, suggesting no true non-responders to PPD.

research INVESTIGATING THE MECHANISMS UNDERLYING THE PATHOGENESIS OF ALOPECIA AREATA

May 2018 in “White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)”

In this study, researchers found that alopecia areata patients show a significant reduction in suppressive regulatory T-cells and an increase in inflammatory T-cell populations, suggesting an immunological imbalance contributing to the disease.

research Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals

18 citations , May 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed significant differences in immune cell infiltration and gene expression across different skin sites, with the back displaying higher tolerance-promoting immune mechanisms, which may enhance epicutaneous immunotherapy outcomes.

research Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation

7 citations , January 2022 in “Biomedicines”

In this study, hair follicle-derived mesenchymal stromal cells showed potential for immunomodulation, with equivalent or superior responses compared to those from adipose tissue, suggesting a promising alternative cell source.

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community Clascoterone won't be available until q4 2027 at the earliest per the newest Cosmo Pharma newsletter

6 upvotes 2 months ago

Clascoterone won't be available in the US until 2028, with EU filings planned for 2027. It's considered an alternative for those who experience side effects from standard treatments like finasteride and dutasteride.

community The Placebo Group Has It Worse Than The Standard Prescription 0.5mg Group. -The fear is all in your head.

190 upvotes 11 months ago

Dutasteride at 0.5mg may have fewer sexual side effects than expected, with many side effects attributed to psychological factors (nocebo effect). The placebo group experienced more side effects, suggesting fear and anxiety might contribute to perceived side effects.

community Clascoterone - what we have right now

24 upvotes 7 months ago

Clascoterone is a topical treatment for androgenetic alopecia, showing modest to moderate hair regrowth, and may be available by 2027-2028. It is considered safer than finasteride, with discussions on its effectiveness compared to RU58841 and pyrilutamide.

community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community How likely do you think it is for PP405 to come out?

in Research/Science 21 upvotes 11 months ago

PP405 is a potential new hair loss treatment that works through metabolic pathways rather than hormonal ones, with an estimated market release between late 2027 and 2029. Current alternatives to finasteride include minoxidil, pyralutamide, fluridil, and RU58841, with hair transplants also being a viable option.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

Is a hair transplant in Turkey safe? Clinics in Turkey describe their own work as safe when it is done in a licensed clinic by an experienced surgeon, and they also agree that quality varies a lot between clinics. All of that comes from the clinics themselves rather than from independent regulator or complication data, so any judgement rests on the specific clinic and surgeon, not on the country.

learn Thymosin Beta 4

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