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Glossary SZ95 Sebocytes

human sebaceous gland cells used in skin research

SZ95 Sebocytes are a type of human sebaceous gland cell line used in scientific research. These cells are derived from sebaceous glands, which are responsible for producing sebum, an oily substance that helps keep the skin and hair moisturized. Researchers use SZ95 Sebocytes to study skin conditions, such as acne and alopecia, and to test the effects of various treatments on sebaceous gland function.

Research

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research Effects of α-Synuclein on the Lipid Phenotype of SZ95 Human Sebocytes: A Preliminary Study in the Context of Parkinson’s Disease

August 2026 in “Cells”

This study investigated the effects of pathological α-synuclein on sebaceous gland cells in Parkinson's disease, finding that α-synuclein exposure altered cellular differentiation and lipid production, suggesting a potential link between α-synuclein and lipid dysregulation in the skin of PD patients.

research Expression of dermcidin in sebocytes supports a role for sebum in the constitutive innate defense of human skin

25 citations , November 2015 in “Journal of Dermatological Science”

In this study, researchers identified the antimicrobial peptide dermcidin in sebocyte lipid droplets, challenging the previous understanding of dermcidin as exclusively sweat-specific.

research Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin

196 citations , May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.

research Inhibition of the Androgen Receptor by Antisense Oligonucleotides Regulates the Biological Activity of Androgens in SZ95 Sebocytes

29 citations , February 2007 in “Hormone and metabolic research”

This study found that antisense oligonucleotides can significantly reduce androgen receptor expression in cultured human sebocytes and may offer new therapeutic possibilities for androgen-associated skin diseases.

research 605 3D-SeboSkin model application in Hidradenitis suppurativa/acne inversa

September 2019 in “Journal of Investigative Dermatology”

This study introduced a reproducible human model using 3D-SeboSkin technology to study hidradenitis suppurativa, allowing better maintenance of skin integrity and replication of biomarker expression patterns compared to traditional skin cultures, suggesting its value for further research.

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