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Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

research Rat steroid 5α-reductase kinetic characteristics: Extreme pH-dependency of the type II isozyme in prostate and epididymis homogenates

13 citations , August 1995 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that the pH dependency of rat steroid 5α-reductase type II isozyme significantly affects its kinetic properties, including Vmax and Km, suggesting past discrepancies in literature may arise from these pH variances during assays.

research Harm reduction measures in a recreational gym user with anabolic androgenic steroid dependence: a case report in the context of current best clinical practice

2 citations , August 2025 in “Harm Reduction Journal”

This study highlights the severe health risks and dependence associated with non-medical androgen use among gym-goers, stressing the need for specialized primary care and harm-reduction strategies due to potentially fatal outcomes even after prolonged cessation.

research Sex dependent influence of a functional polymorphism in steroid 5‐α‐reductase type 2 (SRD5A2) on post‐traumatic stress symptoms

35 citations , March 2013 in “American Journal of Medical Genetics Part B Neuropsychiatric Genetics”

This study found that a genetic variation in SRD5A2 influences the severity of PTSD symptoms in a sex-specific manner among traumatized African-American males.

research Severe steroid-dependent idiopathic angioedema with response to rituximab

16 citations , August 2011 in “Annals of Allergy Asthma & Immunology”

This report describes a case of a 19-year-old woman experiencing severe recurrent angioedema with airway issues, leading to multiple emergency visits and unsuccessful treatment with typical steroid-sparing agents.

In Vivo Time-Dependent Inhibition of Human Steroid 5α-Reductase by Finasteride

research In Vivo Time-Dependent Inhibition of Human Steroid 5a-Reductase by Finasteride

29 citations , January 1996 in “Journal of Pharmaceutical Sciences”

This study developed a theoretical model that suggests finasteride may completely inhibit 5AR type 2, but not sufficiently suppress type 1, leading to only partial reduction of dihydrotestosterone at clinical doses.

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community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

288 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community Progress- 3 months, 5% Minoxidil, 0.1% Finasteride

in Is this regrowth? 232 upvotes 1 year ago

The user experienced significant hair loss after stopping a treatment of 5% Minoxidil and 0.1% Finasteride, which they had used from December 2021 to January 2024. They resumed the treatment in April 2025, hoping for regrowth, and are considering additional treatments like transplants and steroid injections.

community Dutasteride Vs. Testosterone, who wins?

in Finasteride/Dutasteride 58 upvotes 2 years ago

The conversation discusses whether 2.5mg of dutasteride or 200mg of testosterone weekly is more influential in preventing hair loss, with various personal experiences indicating that the effectiveness is dependent on the individual's genetic profile. Some users report that dutasteride is likely to be more effective at the given doses.

community is anyone using ru58841 against acne?

in Technology 3 upvotes 1 year ago

RU58841 is discussed as a potential treatment for acne and hair loss, with users debating its effectiveness and safety compared to other treatments like finasteride, minoxidil, and dutasteride. Concerns about RU58841's side effects and lack of clinical trials are raised, while some users share their personal experiences and routines involving RU58841 for hair loss.

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Hydrocortisone

Can hydrocortisone be used together with other treatments like minoxidil or steroid injections? Clinicians do use a mild steroid cream to settle the scalp irritation minoxidil can cause, but no verified trial tests hydrocortisone added to minoxidil or to corticosteroid injections, and prolonged scalp use risks skin thinning — combining it is a decision to take with a prescriber.

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