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research Innovations in skin microphysiological systems for nonclinical testing and FDA modernization

January 2026 in “Microsystems & Nanoengineering”

This review discusses advancements in skin microphysiological systems, such as 3D bioprinting, skin organoids, and skin-on-a-chip, and their effectiveness in emulating human skin functions for research and preclinical applications, highlighting the potential for replacing animal testing with these innovative technologies.

research Recent advances in understanding the role of the skin microbiome in the treatment of atopic dermatitis

18 citations , September 2023 in “Experimental Dermatology”

This review examines the role of skin microbes in enhancing the skin barrier and their involvement in skin diseases like atopic dermatitis, while also discussing current and future therapeutic strategies targeting the skin microbiome.

research Human relevant platforms for cutaneous wound healing research: current landscape, translational gaps, and emerging frontiers

July 2026 in “Frontiers in Bioengineering and Biotechnology”

This review highlights the development and assessment of human-relevant models for cutaneous wound healing, emphasizing that a combination of systems, such as organoid platforms and skin-on-a-chip systems, is necessary to overcome limitations of traditional methodologies and address chronic wound challenges.

research Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

32 citations , June 2024 in “Pharmaceutics”

This review explores the use of topical and transdermal delivery for drugs and cosmetics, highlighting the benefits of avoiding side effects and rapid metabolism, with a focus on nanoparticulate formulations and techniques for studying skin penetration.

research Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

208 citations , January 2013 in “Lab on a Chip”

The researchers described a chip-based bioreactor platform for dynamic perfusion, which may enhance in vitro skin models by introducing mechanical shear stress and extending culture periods.

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community A Nuanced Look at Microdosing Topical Finasteride

86 upvotes 2 years ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

community DIY Dutasteride Mesotherapy....THE ULTIMATE EXPERIMENT WITH RESULTS!

154 upvotes 5 years ago

User tried DIY Dutasteride Mesotherapy for hair loss due to unsatisfactory Finasteride results. Used mesotherapy injection gun and liquid dutasteride for better results and fewer side effects.

community Haircafe video on Min Sulfate, thoughts?

in Research/Science 101 upvotes 10 months ago

Minoxidil sulfate is considered for those unresponsive to regular minoxidil, with some trying a 10% formulation from Folligenz. Concerns exist about the product's stability and transparency, but some users report positive initial results.

community It looks like Pelage are giving hints that PP405 is a game changer

in Chat 239 upvotes 5 months ago

PP405 is seen as a potential breakthrough for converting vellus hairs to terminal hairs, with users expressing both hope and skepticism. It is compared to treatments like minoxidil and finasteride, with discussions on side effects and marketing concerns.

community 3 months in on oral Dut/Min. The shed is REAL

45 upvotes 4 months ago

The user is experiencing significant hair shedding after three months on oral Dutasteride, Minoxidil, and Vitamin D3, but remains hopeful as shedding can indicate treatment effectiveness. They consider adding topical Minoxidil and dermal needling, while others advise patience.

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