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The Role of Sesbania Grandiflora-Derived Biotin and Bambusa Arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

research The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

July 2025 in “Cureus”

In this clinical trial, the researchers observed that a biotin and silica supplement reduced hair fall, increased hair growth rate, and improved skin elasticity, hydration, and nail quality over 90 days without adverse effects.

Characterization of Plant-Based Biotin from SesZenBio and In Silico Studies to Prove Its Potential in Hair Care

research Characterization of Plant-Based Biotin from SesZenBioTM and In silico Studies to Prove Its Potential in Hair Care

May 2022 in “International Journal of Biochemistry Research and Review”

The researchers characterized a plant-based biotin supplement, SesZenBioTM, from Sesbania agati leaves, predicting it may enhance hair follicle growth more effectively than synthetic biotin based on molecular interactions and its biotin content.

research In-silico studies in herbal drugs: A review

April 2018 in “Journal of Ayurvedic and herbal medicine”

This study highlights the role of bioinformatics and in-silico studies for identifying drug targets, specifically in herbal drugs, using software and modern techniques to analyze data and model disease pathways before later-stage in vivo and in vitro testing.

research Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods

3 citations , October 2018 in “Revista de Chimie”

This review discusses the potential medicinal properties and pharmacokinetic features of nettle compounds ursolic acid and quercetin, highlighting quercetin as a promising candidate for antioxidant and anti-aging effects, but reports no new clinical results.

research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

In this in silico study, researchers analyzed nonsynonymous SNPs in the LIPH gene linked to hypotrichosis and identified three potentially harmful variants (W108R, C246S, and H248N) out of 215 total, using sequence- and architecture-based bioinformatics techniques to differentiate between harmful and benign SNPs.

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Community Join

5 / 26 results

community 14 Months Dut/Minox/Microneedling + 13 Months HRT

38 upvotes 5 months ago

The user shared their hair regrowth journey using treatments like dutasteride, minoxidil, microneedling, tretinoin, Nizoral, silica, biotin, and hormone replacement therapy (HRT) with cyproterone and estradiol. They reported substantial hairline improvement and some crown thinning, with hopes for further progress.

community 0-5 months and losing hope. all oral. 5mg min, 1.1mg fin, 1mg biotin daily

in Is this regrowth? 8 upvotes 9 months ago

The user is experiencing hair loss and is using oral treatments including 5mg minoxidil, 1.1mg finasteride, and 1mg biotin daily. They are considering adding dutasteride and possibly a hair system, while others suggest patience and additional treatments like microneedling.

community Stacking on top of Min/ Fin - adding hair supplements?

in Product 1 upvotes 1 year ago

The conversation is about adding Swisse Hair Nutrition for Men, which contains saw palmetto and various vitamins, to a Minoxidil and finasteride regimen to potentially enhance hair growth. The user is seeking feedback on the effectiveness of stacking these supplements with their current treatment.

community Give me courage, friends! / Is finasteride response correlated with aggressiveness of hair loss?

in Finasteride/Dutasteride 6 upvotes 3 years ago

The user has been using topical finasteride for seven months and minoxidil for three years, with added tretinoin gel for ten months, and is experiencing continuous shedding without signs of regrowth. They are questioning if the amount of shedding is normal at this stage of treatment and if there's a correlation between finasteride response and the rate of hair loss.

community 21M - 8 months on oral minoxidil, crown still thinning. Considering fin - thoughts?

in Finasteride/Dutasteride 9 upvotes 5 months ago

The conversation suggests starting finasteride or dutasteride alongside minoxidil for better hair loss treatment, as minoxidil alone is seen as ineffective without a DHT blocker. Some users also mention considering RU58841 as an alternative to finasteride.

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Learn

6 / 801 results

learn Biotin

supplement to help with hair texture and quality

Biotin: the darling of hair products. Biotin may support hair health, but its effectiveness varies and is often overstated.
Vitamin B7: is it the ultimate secret to healthy hair or just a myth? Biotin is important for hair health, but supplementation is often unnecessary for most people.
How much biotin is too much biotin? The NIH Adequate Intake for adults is 30 mcg of biotin a day, and supplements often contain hundreds of times that; no toxic dose has been identified, but the FDA warns that high-dose biotin can distort blood tests including troponin, so tell your doctor and the lab before any test.

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learn horsetail extract

How does horsetail extract support hair growth — is it the silica, the antioxidants, or both? Horsetail extract supports hair growth primarily through its silica content.

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