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Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil

research Human hair follicles contain two forms of ATP‐ sensitive potassium channels, only one of which is sensitive to minoxidil

102 citations , February 2008 in “The FASEB Journal”

This study found that human hair follicles express ATP-sensitive potassium channels, suggesting that minoxidil acts on these channels and that drugs targeting them may treat hair disorders.

research Investigations into the roles of potassium channels in hair growth : studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches

November 2010 in “Bradford Scholars (University of Bradford)”

In this study, the authors reported that NNC55-9216, a selective SUR1 KATP channel opener, stimulated hair follicle growth in culture and enhanced the effects of minoxidil, suggesting a new potential treatment for hair loss.

Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles

research Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles

July 2023 in “Biomolecules”

This study established a novel in vivo "whisker follicle microinjection assay" using mouse whiskers to evaluate hair growth and pigmentation effects of various chemicals and proteins, identifying minoxidil, ruxolitinib, and RSPO1 as growth promoters, while deoxyarbutin inhibited pigmentation and Nbl1 emerged as a growth inhibitor.

research A highly sensitive MEMS silicon‐hair device reproducing the function of hair follicle

2 citations , August 2019 in “Electronics and Communications in Japan”

This study reports a highly sensitive MEMS silicon-hair device that mimics hair follicle functions by detecting minimal forces and moments, including electrostatic attraction and surface tension of liquids.

research A Highly Sensitive MEMS Silicon-Hair Device Reproducing the Function of Hair Follicle

1 citations , June 2019 in “IEEJ Transactions on Sensors and Micromachines”

This study reports the development of a MEMS silicon-hair device capable of detecting minute forces and moments, replicating the sensory functions of human hair follicles with high sensitivity.

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Community Join

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community Can testosterone alone cause hair loss even after nuking DHT?

in Research/Science 26 upvotes 7 months ago

Testosterone can still cause hair loss even when DHT is blocked by dutasteride, especially if hair follicles are sensitive. Topical treatments like RU58841 or pyrilutamide may help, but their long-term effectiveness is uncertain compared to dutasteride.

community What else can make hair more sensitive to DHT?

17 upvotes 1 month ago

Genetics, inflammation, poor scalp circulation, stress, thyroid issues, low iron, vitamin D deficiency, steroids, age, fungal infections, stress, and creatine can increase hair sensitivity to DHT. Treatments mentioned include dutasteride, minoxidil, and Kre Alkalyn Monohydrate.

community How does testosterone and dht work?

14 upvotes 1 month ago

Hair loss is influenced by follicle sensitivity to DHT, which increases with age, rather than just testosterone levels. Treatments like finasteride and hair transplants are used to manage hair loss, with transplants needing medication to protect surrounding sensitive hair.

community Why not move miniaturized hair follicles somewhere else to treat them? Alternative to hair cloning?

4 upvotes 1 year ago

Exploring the idea of transplanting miniaturized hair follicles to healthier areas to potentially reverse hair loss, with concerns about DHT sensitivity and scar tissue formation. The conversation also humorously considers using mice for hair growth experiments.

community Scalp Skin Barrier Health and Hair Follicle Cycling: A Potential Overlooked Connection

in Technology 4 months ago

The conversation discusses the importance of scalp skin barrier health in hair follicle cycling, suggesting treatments like ceramides or niacinamide to support hair growth. It also mentions the use of finasteride for hair loss.

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Learn

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learn Overview

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Stem Cell Factor

learn Hair Fibers

Are hair fibers safe for sensitive scalps or people with dandruff and irritation? Hair fibers may irritate sensitive scalps and worsen dandruff conditions.

learn capsicum

Is capsicum safe for sensitive scalps or inflammatory hair loss? Capsicum may irritate sensitive scalps and worsen inflammatory hair loss.

learn Sulforaphane

Can sulforaphane improve hair growth in people with sensitive or irritated scalps? Sulforaphane may help improve hair growth by reducing scalp inflammation.

learn Scalp Micropigmentation

Does scalp micropigmentation hurt? Scalp micropigmentation typically causes minimal discomfort, often described as light scratching.
Is scalp micropigmentation safe? Providers describe scalp micropigmentation as low-risk when a trained practitioner uses sterile single-use equipment, but that is a provider claim rather than a regulatory finding: pigment allergy, infection and colour change are documented risks of cosmetic tattooing.

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas